TEAD4 and neoplasm: We also performed a tumorigenesis assay in nude mice and found that knockdown of TEAD4 significantly suppressed the xenograft growth of HCC1806 (Figure 3E–3G); indeed, both tumor weights and volumes in the HCC1806-TEAD4sh#3 group were significantly less than those of HCC1806-Lucsh group (Figure 3F–3G).