In contrast to the slightly increased expression of KNG/BK and B1R in the CRSsNP mucosa, a higher-level expression of the B2R in nasal epithelial cells, stromal fibroblasts, and glands was observed in the CRSsNP mucosa (Fig 8B). The gene discussed is BDKRB1; the disease is chronic rhinosinusitis without nasal polyps.