Some studies point to the inhibition of Jak/signal transducer and activator of transcription 3 (STAT3) signaling being the mechanism responsible for inhibitory effects of cucurbitacins on cancer cells [2], while others support the notion that it is the rapid disruption of the actin cytoskeleton by cucurbitacins being responsible for their anticancer activities [3, 4]. Here, STAT3 is linked to cancer.