Correspondingly, deficiency of such proteins will increase the MLIP, which has been shown for yeast Atm1 raising the mitochondrial iron content by about 30-fold [216] and also holds true for ABCB7 deficiency in humans causing the rare hereditary disease X-linked sideroblastic anemia and ataxia (XLSA/A) [214,217]. This evidence concerns the gene MLIP and X-linked sideroblastic anemia with ataxia.