CXCL9 and neoplasm: In fact, profilers based on the expression of a higher number of genes (CD3Z, CD8, CXCL9, CXCL13 and IGHM) and consisting of 2, 3 or 4 clusters did not show marked gene expression variability between tumour groups, did not improve separation of clusters nor did they exhibit prognostic significance for patient outcome (S1–S3 Figs).