Interestingly, tumour mRNA expression of ESR1 (71 cases, 24.8%) was strongly associated with inferior DFS (HR = 2.33, 95% CI 1.35–4.02, p<0.001) and OS (HR = 1.74, 95% CI 1.02–2.97, p = 0.04). This evidence concerns the gene ESR1 and neoplasm.