Our use of clustered CD3 and CD8 RQ values from CT and IM cores does indeed preclude us from obtaining information on the role of the immune response in each of these two tumour tissue compartments, however it is not different from the IHC Immunoscore strategy of calculating a total score from the addition of the IHC immune infiltrates in CT and IM[12]. The gene discussed is CD8A; the disease is neoplasm.