Among 286 informative CRC cases, the mIS showed robust separation of two patient groups (clusters): Cluster 1 (red dendrogram, n = 188) was characterised by relatively low CD3Z and CD8 mRNA expression in the majority of cases and was called mIS-low, while Cluster 2 (green dendrogram, n = 98) contained cases with higher CD3Z and CD8 mRNA expression and was defined as mIS-high. The gene discussed is CD8A; the disease is colorectal carcinoma.