Right-sided colonic tumours bore increased expression of genes regulating anti-tumour immune reactivity (HOX genes, CD44, CD68, CD163, CD3Z, TNFR, LYN, LCK, NOS, TRAF and FLT4) and reduced expression of genes orchestrating tumour hijack of immune responses in order to promote inflammation, tumour proliferation and immune evasion (PD1, CDX2, ERK, APC, b-catenin, Epithelial Mesenchymal Transition mediators, BCL2 and IL4, 5, 7 and 17). This evidence concerns the gene LYN and colonic neoplasm.