The result showed that relative firefly luciferase activity of reporter plasmids containing the CDK2 3’ UTR binding site was significantly inhibited in colon cancer cells transfected with miR-302s (Fig 7F), indicating that miRs inhibits Cdk2 protein (Fig 7D), but not CDK2 mRNA (Fig 7G). Here, CDK2 is linked to colonic neoplasm.