FOXO3 and arthritic joint disease: In contrast to the protection from K/BxN-serum transfer arthritis provided by a myeloid lineage-specific deletion of Foxo3, it has recently been shown that a noncoding SNP (FOXO3 (rs12212067: T>G)) leads to increased expression of FOXO3 in monocytes during inflammation, limits monocyte inflammatory responses, and is associated with reduced severity of RA [13].