CHRNA4 and autosomal dominant nocturnal frontal lobe epilepsy: Overall, evidence in expression systems tends to favor an epileptogenic mechanisms caused by potentiation of neocortical heteromeric nAChR function, which would be consistent with the observation that deleting either α4 or β2 in murine strains does not lead to seizure facilitation or other aspects of the ADNFLE symptoms [263, 264].