PTGDS and early-onset autosomal dominant Alzheimer disease: For instance, a protein complex of SCRIB, NOS1AP and VANGL1 is associated with breast cancer progression [10], TWIST/Mi2/NuRD protein complex has an essential role in cancer metastasis [11], aberrant protein complex consisting of prostaglandin-d-synthase (PDS) and transthyretin (TTR) is a biomarker of Alzheimer’s disease [12].