The link between TRAPS and atherosclerosis can be mediated also by adipokines, as it has been demonstrated on one hand, that serum leptin significantly correlates with markers of subclinical atherosclerosis [44] and elevated adiponectin with a higher risk of cardiovascular disease [45] and, on the other hand, preliminary research showed a correlation between serum leptin and adiponektin and disease activity and/or severity [46]. This evidence concerns the gene LEP and TNF receptor 1-associated periodic fever syndrome.