Although IL-27 is negatively correlated with Th17 cell, our data showed that no association of IL-27 with IL-17 was found in NSCLC patients, indicating that the higher circulating IL-17 levels may originate from Th17 cells and any other NK cells and that IL-27 levels may have little effect on the secretion of IL-17 in NSCLC patients. Here, IL17A is linked to non-small cell lung carcinoma.