Pal and colleagues demonstrated that PRMT5 overexpression in mantle cell lymphoma was dependent on down-regulation of the PRMT5-targeting miRNAs miR-92b and miR-96 [72]; in leukemia and lymphoma cells, PRMT5 was found to be also targeted by miR-19a, miR-25, miR-32 and miR-197 and to inhibit the expression of TS belonging to Rb family [73]. Here, PRMT5 is linked to mantle cell lymphoma.