In hepatocellular [51], endometrial cancer [52] and osteosarcoma [53], the tumor suppressive miR-101 targets EZH2, the catalytic subunit of the PRC2 (Polycomb Repressive Complex 2) complex, which is responsible of the H3K27me3-mediated silencing of tumor suppressor genes in cancer [54]. The gene discussed is EZH2; the disease is neoplasm.