Epigenetic events are involved in the regulation of RANK-L expression in MM cells: Yan et al. recently demonstrated that TNFα in the BMM promotes RANK-L promoter demethylation, and this relies on a molecular circuitry which involves miR-140 and miR-126-3p, both known to repress DNMT1 translation [145]. This evidence concerns the gene DNMT1 and Miyoshi myopathy.