On the other hand, MMSET is able to enhance the proliferation of MM cells by stimulating the expression of c-MYC at the post-transcriptional level: this occurs by increased trimethylation of H3K9 and decreased H3 acetylation of miR-126*, which results in miR-126* down-regulation and consequent increase in its target c-MYC [69]. This evidence concerns the gene NSD2 and Miyoshi myopathy.