Evidence of epi-miRNA activity of miR-29b has been widely provided in AML: as observed in MM, enforced expression of miR-29b in AML cells results in marked reduction of the expression of DNMT1, DNMT3A, and DNMT3B at both RNA and protein levels; this in turn led to decrease in global DNA methylation and re-expression of tumor suppressors p15(INK4b) and ESR1 through promoter DNA hypomethylation. Here, DNMT3B is linked to acute myeloid leukemia.