Among them, we confirmed that cleavage and polyadenylation-specific factor CPSF6, poly (A)-specific ribonuclease PAN2 and cytoplasmic poly (A)-binding protein PABPC1 (ref. 15) were associated with FUS in the brain (Fig. 3e), primary neurons and neuroblastoma cells (Supplementary Fig. 8). Here, PAN2 is linked to neuroblastoma.