Generally, maximum titers of baseline and treatment-induced antibodies within each population were of similar magnitude, with two exceptions: Trial 117–206 (type II diabetes, co-administered with insulin) where the maximum titer increased following exposure, but was still only at a median of 160, and trial 160603/902 (primary immunodeficiency, co-administered with human IgG) where the highest titers in all of the trials were observed in five subjects (Fig. 2). Here, INS is linked to type 2 diabetes mellitus.