Generally, maximum titers of baseline and treatment-induced antibodies within each population were of similar magnitude, with two exceptions: Trial 117–206 (type II diabetes, co-administered with insulin) where the maximum titer increased following exposure, but was still only at a median of 160, and trial 160603/902 (primary immunodeficiency, co-administered with human IgG) where the highest titers in all of the trials were observed in five subjects (Fig. 2). This evidence concerns the gene INS and inborn error of immunity.