Circulating inflammatory cytokines in patients with inflammatory disease likely play an important role in bone homeostasis, since individual cytokines such as IL-1β enhance osteocyte-mediated osteoclastogenesis [10], and serum from patients with active RA inhibits osteoblast proliferation and differentiation, and enhances osteoblast-mediated osteoclastogenesis [8]. The gene discussed is IL1B; the disease is rheumatoid arthritis.