We found that RA serum did not affect the intrinsic capacity of osteocytes to sense mechanical stimuli, i.e., the osteocytes showed an unchanged NO response to PFF, although PGE2 production was affected, and an unaltered gene expression of IL-6, COX2, CYR61, MEPE, and SOST. This evidence concerns the gene SOST and rheumatoid arthritis.