VEGFD and neoplasm: Our data indicate that the VEGFR-2 activating pathway with the ligands VEGF-C and VEGF-D and the phosphorylated receptor forms pVEGFR-2Tyr1175 and pVEGFR-2Tyr1214 is closely involved in events affecting tumor cells themselves as well as components of the tumor microenvironment related to blood supply, angiogenesis and inflammatory response in colon carcinoma.