In fact, the observation of increased OPC numbers, the presence of alpha-synuclein accumulation within a subset of striatal OPCs in MSA patients, and the interference of alpha-synuclein with OPC maturation suggest that not only mature OLGs are affected in MSA demanding the generation of transgenic models expressing alpha-synuclein controlled by more immature oligodendroglial promoters, e.g., PDGF receptor alpha [174, 182, 183]. Here, SNCA is linked to multiple system atrophy.