TCF4 and neurodevelopmental disorder: Several genes associated with neurodevelopmental disorders include genes coding for channels (for example, GRIN2B, SCN2A) and synaptic adhesion proteins such as NRXN1 or NLGN4X. All of the genes that we have tested to date (TCF4, EHMT1,33SATB2 and MBD5) are thought to act as transcriptional repressors either through direct interaction with DNA or indirectly through protein complex intermediaries, and lead to increased NSC differentiation when gene dosage is suppressed.