SATB2 and cleft palate: Special AT-rich binding protein 2 (SATB2) is a transcription factor that associates with AT-rich regions of the genome and the nuclear matrix,21, 22 and is thought to be involved in chromatin modification in neurons.23SATB2 is found on 2q33.1 and reduced dosage of SATB2 is thought to be a major cause of 2q33.1 deletion syndrome,24 characterized by cleft palate,25 severe speech delay, intellectual disability and behavioral problems, including ASD.24, 26