HNF4A and hepatocellular carcinoma: Our findings also reveal the role of Gα12 pathway in the activity of hepatocyte nuclear factor 4α (HNF4α) required for the expression of MIR122. To verify the relationship between decrease of miR-122 by Gα12 and HCC progression, the levels of Gα12, miR-122, or c-Met were measured for human HCC samples and correlated with changes in recurrence-free and overall survival rates of the patients.