There was change in TF during the study period: compared to 2004–2008, patients treated at 2009/2014 had a relative risk reduction of 0.86 (95% confidence interval [CI] 0.77–0.96) and three independent risk factors were identified: period of treatment at 2009 and 2014, sepsis and age > 65 years. The gene discussed is TF; the disease is Sepsis.