The TIMP3 gene is coded at chromosome 22q12, is currently the best understood tumor suppressor gene being altered by epigenetic mechanisms in meningiomas [9]; of note epigenetic inactivation of TIMP3 has been recently associated with a more aggressive and higher-grade (grade II-III) meningioma phenotype [9, 17, 18]. This evidence concerns the gene TIMP3 and meningioma.