In addition, an association between the NF2 gene and tumor localization has also been reported; Kros et al. [13] demonstrated that tumors of the convexity are more prone to have NF2 mutations than anterior cranial-based tumors, and Clark et al. [14] recently correlated meningiomas with mutant NF2 and/or chromosome 22 loss with tumor localization in the cerebral and cerebellar hemispheres. This evidence concerns the gene NF2 and meningioma.