Interestingly, calcium channel antagonists can block in vitro primary meningioma cell growth after stimulation with EGF and PDGF, as well as in vivo meningioma growth in a subcutaneous meningioma mouse model [66]; the specific mechanisms involved in such blockade of IP3-mediated intracellular calcium signaling pathways in meningiomas, still deserves further investigation. Here, EGF is linked to meningioma.