In addition to del(6q), Pérez-Magán et al. [31] also reported overexpression of the histone cluster 1 genes coded at chromosome 6p (e.g. the HIST1H1c gene) in 27% and 89% of primary and recurrent meningiomas, respectively; recent results suggest that physical interaction of the H1.2 protein could be involved in epigenetic regulation of gene expression by maintaining specific DNA methylation patterns, but its functional role in meningiomas still remains to be elucidated. The gene discussed is H1-2; the disease is meningioma.