In contrast with other chromosomal alterations, the role of chromosome 9 in the development of malignant meningiomas is better defined, since it has been mostly associated with three tumor suppressor genes coded at chromosome 9p21: CDKN2A/p16INKa, CDKN2A/p14ARF and CDKN2B/p15ARF. This evidence concerns the gene CDKN2B and meningioma.