AP1B1 and meningioma: In this regard, an early report found BAM22 –a gene from the β-adaptin family coded at chromosome 22q12– to be inactivated in 9/71 meningiomas [15], and another more recent study found reduced expression of the BCR (breakpoint cluster region) gene coded at chromosome 22q11 in meningiomas with 22q LOH [16], further supporting the existence of candidate genes other than NF2 in the pathogenesis of meningiomas (Table 1).