NF2 and meningioma: Recently, the AKT1 gene (coded at chromosome 14q32) has been reported to be mutated in meningiomas lacking NF2 mutation [14, 23], the reported mutation (E17K) resulting in constitutive AKT1 activation [23]; therefore, the AKT1 gene has become one of the most attractive target genes for cases with monosomy 14/del(14q).