Of note, several genes coded in these chromosome have been recently identified by next generation sequencing as recurrently altered in meningiomas; among others, these include the AKT1 (E17K mutation), SMO (L412F and W535L mutations), KLF4 (K409Q mutation) and TRAF7 (several mutations mapped at the WD40 domains) genes [14, 23, 24]. This evidence concerns the gene SMO and meningioma.