RPS6K (ribosomal protein S6 kinase; p70S6K) is a proto-oncogene coded at chromosome 17q23, which has been found to be overexpressed at the protein level [46]; however, amplification of this gene appears to occur only in a small subset of higher grade meningiomas, even when amplification of the loci adjacent to this gene is present [47], suggesting that other genes coded in the vicinity of RPS6K may be the main targets for 17q amplification. The gene discussed is RPS6KB1; the disease is meningioma.