Further analysis demonstrated that out of the 187 HCC tissues, in which C/EBPβ expression was downregulated compared with non-tumorous liver tissues, 75.40% (141/187) of cases also had lower ORM2 protein expression compared with non-tumorous liver tissues, 20.32% (38/187) of cases had similar expression, and only 4.28% (8/187) had higher expression in HCC tissues. Here, ORM2 is linked to hepatocellular carcinoma.