In addition, the activity of nuclear factor-kappa B (NFκB), a transcription factor repressing the expression of HNF4α, is attenuated by ITLN1 via inactivation of phosphoinositide 3-kinase (PI3K)/AKT/Ikappa B kinase (IKK) signaling, suggesting the tumor suppressive roles of ITLN1 in gastric cancer. Here, HNF4A is linked to neoplasm.