In contrast, stable knockdown of ITLN1 induced the phosphorylation of AKT (T308 and S473), IKKα/β (S180/S181), IκBα (S32/S36), and NFκB-p65 (S536) in gastric cancer cells, which were abolished by administration of PI3K activity inhibitor LY294002 and IKK inhibitor BAY11-7082 (Figure 3B). This evidence concerns the gene AKT1 and gastric cancer.