The HNF4α promoter region contains several binding sites of transcription factors, such as hepatocyte nuclear factor 1 alpha, specificity protein 1, hepatocyte nuclear factor 6 alpha, and GATA binding protein 6, which are crucial for high HNF4α expression in hepatocellular carcinoma and hepatoblastoma cells [38]. This evidence concerns the gene SP1 and hepatocellular carcinoma.