KIT and neoplasm: The IC-2N508I cellsproliferated in a cytokine-independent manner and showed KIT auto-phosphorylation.Subcutaneous injection of IC-2N508I cells into the dorsal area ofimmunodeficient BALB/c-nu/nu mice resulted in the formation of solid tumors,but tumor progression was abrogated by treatment with a tyrosine kinase inhibitor(STI571).