TIMP1 and Granuloma: The early increase in MMP13 gene expression at 4hrs which decreased over time (5|1.9|1.3), coupled with the opposite expression of TIMP1 which was unchanged at 4 and 24hrs and then increased at 24hrs (-1.1|-1.1|2.1) may explain the decrease in collagen deposition which was observed in the direct core of schistosome-induced granuloma.