In various diseases such as anemia, Wilson's disease, leukemia and lymphoma, acute and chronic infection, biliary cirrhosis, carious teeth, hemochromatosis, collagen diseases, hypothyroidism, hyperthyroidism, etc., the copper concentration is increased and mainly associated with increased C-reactive protein (CRP) [14, 23–25]. Here, CRP is linked to hemochromatosis type 1.