Owing to the fact that RSV possesses strong anti-inflammatory effects in various cells and tissues, the SIRT1 enzyme is present in skin and NF-κB is important in the development of psoriasis, we decided to study whether RSV might possess positive effects on Imiquimod (IMQ)-induced psoriasis-like skin inflammation in the mouse model described by van der Fits et al. [15] and furthermore, identify potential candidate genes, pathways and interleukins responsible for the observed effect. The gene discussed is SIRT1; the disease is psoriasis.