Activation of NF-κB is a key factor in the development of psoriasis [7] and in a previous study, RSV has been shown to inhibit NF-κB [12] and decrease NF-κB activity in cultured keratinocytes exposed to LPS, TNFα and IFN-γ [19].These findings and the fact that SIRT1 one is present in skin led us to test whether or not RSV in vivo would have an effect on psoriasis-like skin inflammation in a mouse model. The gene discussed is NFKB1; the disease is psoriasis.