The discovery that the MALT1 (Entrez Gene ID 10892) and BCL10 genes are involved in translocations commonly found in B-cell lymphomas of mucosa-associated lymphoid tissue (MALT lymphomas) in turn led to the identification of the so-called ‘CBM signalosome’, which is a heterotrimeric complex between any one of several different members of the CARMA protein family, with BCL10 and MALT1 [1]. This evidence concerns the gene BCL10 and B-cell non-Hodgkin lymphoma.