SCN1A and Dravet syndrome: In order to be able to rapidly analyze the potential anti-epileptic activity of fenfluramine, we developed a zebrafish model for this disorder using morpholino antisense oligomers targeting scn1Lab, the zebrafish ortholog of SCN1A. Here we describe the pathophysiological and pharmacological characterization of this zebrafish DS model, which displays abnormal locomotor behavior, recurrent electrographic discharges and age-dependent hyperthermia sensitivity.