SOCS3 and melanoma: Examples of such studies include investigations into the combination of the adjuvants CpG and MF59 for enhanced vaccine efficacy [1], into the combination of the multi-kinase inhibitor sorafenib and the non-steroidal anti-inflammatory drug diclofenac in the treatment of melanoma [2], into the effect of the co-deletion of phosphatase and tensin homologue (PTEN) and suppressor of cytokine signalling 3 (SOCS3) on axon regeneration [3], and into the combined effects of a model air pollutant and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine on genome-wide gene expression [4].