Analysis of data from The Cancer Genome Atlas (TCGA) using the cBIO portal across most cancer types shows genomic alterations in IGF ligands (IGF1, 2), receptors (IGF1R, IGF2R), binding proteins (IGFBP1–6), and IRSs (IRS1, 2, 4); this representing 18 genes (Figure 1A). The gene discussed is IGF2R; the disease is cancer.