ITGAX and arthritic joint disease: Even though there was a significant reduction of Tregs, and the number in the spleen inversely correlated with arthritis, the cause of the arthritis is more complex since deletion of Tregs results in fatal autoimmunity, with autoreactive T cells infiltrates in the pancreas, thyroid and intestine11, 48, which were not observed in the CD11c-Flip-KO mice.