Given 1) the findings of Yeh et al. [5], which are concordant with a wealth of data on the active role of IL-18 in the dissemination of other cancers, and 2) the widely dispersed microsatellites within the brain tissues that go on to be fatal in glioblastoma, the safest supposition for now is that the net effect of IL-18 in glioblastoma is negative. Here, IL18 is linked to cancer.