Moreover, although two large RCTs (HALT-C & EPIC3)4, 5 have examined the impact of PEG-IFN treatment on CHC cirrhotic patients, most of the enrolled patients failed initial antiviral treatments and received half-dose regimens, the long-term outcomes after PEG-IFN-based therapy in treatment-naive HCV cirrhotic patients remain unclear. Here, IFNA1 is linked to cryohydrocytosis.