G3BP1 and breast cancer: As shown in Figure 7B, the average weight of the 4T1/Mock tumors was much larger than that of the 4T1-luc/G3BP1(−)-1, 4T1-luc/G3BP1 (−)-2 and 4T1-luc/G3BP1(−)-1/2 tumors, suggesting that G3BP1 significantly promoted tumorigenesis and growth in this orthotopic breast cancer model and that G3BP1 downregulation suppressed primary tumor growth.