G3BP1 and neoplasm: Although G3BP1 was overexpressed in many tumor samples compared to healthy tissue [21], the up-regulation of G3BP1 promoted an invasive and metastatic phenotype in non-metastatic breast cancer MCF-7 cells, whereas the down-regulation of G3BP1 suppressed this invasive and metastatic phenotype in metastatic MDA-MB-231 breast cancer cells.