A Nigerian study assessed glucose and insulin responses to an oral glucose load among offspring of parents with type 2 diabetes mellitus (T2DM) and found higher levels of fasting plasma glucose, fasting plasma insulin, and two-hour post-glucose load plasma insulin, indicating a higher risk for developing diabetes.55 A Cameroonian case–control pedigree study showed increased prevalence of diabetes and impaired glucose tolerance in the offspring of parents with T2DM.56 Here, INS is linked to type 2 diabetes mellitus.