A single study from Egypt noted that the presence of the ACE D allele significantly predisposed to stroke in children with sickle cell anaemia.112 It is, however, significant to note that the people of North Africa have a different ancestral origin (predominantly Arabian and Berber) from sub-Saharan African populations.9 Therefore, significant differences may be anticipated in the genomic profile of stroke and subtypes in sub-Saharan Africans. Here, ACE is linked to stroke disorder.