Saidi and colleagues working consistently with a growing Tunisian stroke cohort have reported significant association between ischaemic stroke and polymorphisms in several genes, including plasminogen activator inhibitor, APOE ε4, human plasminogen activator, human platelet antigen, angiotensin converting enzyme Del/Del genotype, angiotensinogen, endothelial nitric oxide synthase and aldosterone synthase.104-111. This evidence concerns the gene APOE and stroke disorder.