Genes involved in the renin–angiotensin–aldosterone system, coagulation pathway, lipid metabolism, homocysteine metabolism and inflammation are among the most explored.83 The APOE ε2 and APOE ε4 genes have been associated with lobal ICH in Caucasian, Asian and African American populations with a high prevalence of cerebral amyloid angiopathy (CAA).84,85. Here, APOE is linked to cerebral amyloid angiopathy.