Similarly, while the associations between cetuximab and MET are currently limited to the setting of colorectal cancer, MET amplification and activation were associated with acquired resistance to cetuximab in treated patients, and cetuximab-induced MET activation was found to contribute to cetuximab resistance in certain colon cancer cell lines (Table 1) [98,99]. The gene discussed is MET; the disease is malignant colon neoplasm.