EGFR and cancer: The same study further supports such a heterodimer-mediated mechanism of resistance by demonstrating strong anti-proliferative effects when these cancer cells were treated with both an inhibitor of HER2/3 heterodimerization and cetuximab, which suggests that HER2/3 heterodimers also help mediate cetuximab resistance in an EGFR-dependent manner (Table 1) [101].