With respect to cetuximab, while no specific evidence links genetic variations in NF-κB or NFKBIA with drug efficacy on NSCLC, patients with colorectal cancer whose tumors are negative for NF-κB expression have a positive predictive response to cetuximab and a longer overall survival compared with patients whose tumors are positive for NF-κB expression; the results were similar after erlotinib treatment in patients with NSCLC (Table 1) [1,88]. The gene discussed is NFKBIA; the disease is non-small cell lung carcinoma.