However, some severe complications due to reactivated VZV seen in RA, inflammatory bowel disease (IBD), Crohn’s disease, ankylosing spondylitis, plaque psoriasis and psoriatic arthritis patients receiving anti-TNF treatments to reduce the host immune response suggests that whole-body treatment by anti-TNF injectable biologics may not be an optimal therapy for all PHN patients [82,126-132]. Here, TNF is linked to rheumatoid arthritis.