While antibodies that interfere with TNFα such as Etanercept, Adalimumab and Infliximab have been successfully employed to relive pain in patients with rheumatoid arthritis, inflammatory bowel disease and other immune complications, reports vary widely for treatment of PHN pain with some showing efficacy without complications in patients with herpes zoster (HZ), ZAP or PHN, while others suggest that the severity and risk of PHN are dramatically increased [80-82]. The gene discussed is TNF; the disease is inflammatory bowel disease.