At histology breast cancer was a hormone-sensitive (ER+ 70 %, PR+ 20 %), in situ ductal breast carcinoma with micro-infiltrating spots (<1 mm), (pT1mic, pN0M0 G2, Ki67 10 %, c-erb B2 DAKO HerceptTest 1+ neg). The gene discussed is ESR1; the disease is breast carcinoma.