No association with COPD has been reported for NCOR1, a co-repressor of PPAR δ, γ, and an antagonist of β-catenin [70], but the known involvement of the Wnt β-catenin pathway in abnormal airway responses in COPD patients [71, 72] and the established protective role of PPARγ activation against COPD [73–75] warrant further investigations related to the predicted activation of NCOR1 in COPD-susceptible mouse models. This evidence concerns the gene PPARG and chronic obstructive pulmonary disease.