If malaria continues to decline, and testing rates are of only a portion of febrile patients, increasingly rare malaria cases may be missed despite the high sensitivity and specificity of the histidine-rich protein 2 (HRP2)–type RDTs (used in Senegal).35 Missed malaria cases pose a challenge for malaria eradication and may eventually affect confidence in T&T policies and lead to practitioners reverting to presumptive diagnosis. Here, HDGFL2 is linked to malaria.