Ischemic stroke and Alzheimer's disease (AD), despite being distinct disease entities, share numerous pathophysiological mechanisms such as those mediated by inflammation, immune exhaustion, and neurovascular unit compromise, for example PKC (protein kinase C)-dependent events and β-amyloid production may serve as an important connection linking age-related brain injury [31]. Here, PRRT2 is linked to early-onset autosomal dominant Alzheimer disease.