CCNB1 and colorectal cancer: Then the 150 patients with colorectal cancer were divided into two groups: high Cyclin B1 expression group (n = 88) that Cyclin B1 expression ratio ≥ 3.33, and low Cyclin B1 expression group (n = 62) that Cyclin B1 expression ratio < 3.33, according to the cut-off level (Fig 2B).