Moreover, Hey-2 mRNA expression was higher in women with PE that gave birth with a cesarean section compared with women with PE that gave birth naturally, a finding also observed for PHD3 in our FGR study [19], and can probably be attributed to less stress during delivery and the fact that women that gave birth with a cesarean section had more severe preeclampsia than women who gave birth naturally. Here, HEY2 is linked to preeclampsia.