NOTCH3 and preeclampsia: Other studies, however, have failed to detect any differences in NOTCH2 and DLL4 expression between PE and normal placentas [8], have observed an increase in JAG1 expression through pregnancy [16], or while agreeing with our observations regarding NOTCH2 downregulation, they found NOTCH3 to be overexpressed [17], albeit in early-onset severe preeclampsia (gestation period 24–33 wks).