Previous studies have demonstrated critical roles for NLRP3 inflammasome activation in the immune responses of many diseases, such as asthma [14], T-cell-dependent immune complex glomerulonephritis[15], acute graft-versus-host disease (GvHD)[16], systemic lupus erythematosus (SLE)[17], metabolic disorders like type 2 diabetes[18], gout, and pseudogout [19]. The gene discussed is NLRP3; the disease is systemic lupus erythematosus.