FOXM1 and cancer: Recent evidence also suggests FOXM1 can protect cells from genotoxic agent-induced senescence by enhancing DNA repair.11, 12 Consistently, FOXM1 is overexpressed in genotoxic agent-resistant cancer cells.11, 13 FOXM1 has been implicated in paclitaxel resistance but the exact mechanism by which FOXM1 modulates the anticancer effects of paclitaxel remains undefined.