Related to this, previous data have shown that CCR7 mRNA expression in monocytes is controlled by p38 MAPK signaling.25 The CCR7 promoter contains binding sites for AP-1 factors (Figure 4d), and such factors have been shown to promote CCR7 expression in Hodgkins lymphoma and metastatic squamous carcinoma cells of the head and neck.26, 27 On the basis of this, and the fact that AP-1 factors are activated during, and important for the induction of TGF-β1-induced EMT,17, 28 we hypothesized that specific AP-1 factors could be involved in inducing CCR7 expression during TGF-β1-induced EMT. The gene discussed is FOS; the disease is Hodgkins lymphoma.