These data are in line with other reports showing that the expression of CCR7 is associated with poor prognosis and lymph node metastasis in breast cancer.35, 36, 37 Recently, Shields et al.38 reported on a role for autologous, CCR7-mediated chemotaxis of tumor cells toward lymphatic endothelial cells in 3D matrices. Here, CCR7 is linked to breast carcinoma.