These data are in line with other reports showing that the expression of CCR7 is associated with poor prognosis and lymph node metastasis in breast cancer.35, 36, 37 Recently, Shields et al.38 reported on a role for autologous, CCR7-mediated chemotaxis of tumor cells toward lymphatic endothelial cells in 3D matrices. The gene discussed is CCR7; the disease is metastatic malignant neoplasm in the lymph nodes.