Surprisingly, deletion of Runx3 in adult mouse lung results in the early induction of lung adenomas of either the mucinous or non-mucinous type.21 Simultaneous targeting of Runx3f/f and K-RasLSL-G12D/+ led to the progression of the two distinct types of adenomas into the corresponding types of adenocarcinomas. The gene discussed is RUNX3; the disease is adenocarcinoma.