The inhibition of VEGF by miRNA126 impaired activation of the MAPK pathway, and resulted in two actions: (1) Inhibition of the MAPK pathway directly reduced the expression of many inflammation-related cytokines responsible for the increased instability of atherosclerosis plaques [32, 33, 34] and (2) Inhibition of the MAPK pathway inhibited formation of FOS and JUN dimers, which decreased the activity of AP1, down-regulated BCL-2, and which might be able to reduce the apoptosis-resistant endothelial cells at lesion area. This evidence concerns the gene FOS and atherosclerosis.