MMP9 and neoplasm: Inhibition of MMP9 also limited the ability of the primary tumor to colonize distal sites: mice in the anti-MMP9 (m+h) treatment group in Studies 1 and 2 (Fig 7I and 7H) had significantly reduced metastasis vs. the isotype control—and in Study 3 (Fig 7G), the metastases reduction in the anti-MMP9 (m+h) group closely approached significance (p = 0.0502 vs. isotype control).