A large body of data also supports targeting of MMP9 in CRC [35–38] and in other oncology indications [5, 6]: MMP9 has been investigated as a key player in metastasis and invasion for over two decades (e.g. see [112, 113]), and has subsequently been shown to be involved in other facets of cancerous growth, including priming of the metastastic niche and modulation of growth signaling [2, 5, 53, 64–68]. This evidence concerns the gene MMP9 and colorectal carcinoma.