MMP9 and neoplasm: Interestingly, inhibition of hMMP9 or mMMP9 either singly or in combination yielded significant reductions in tumor growth rate (Fig 7A, 7B and 7C) and in final tumor weight (Fig 7D, 7E and 7F) vs. the isotype-control group (inhibition with anti-MMP9 [m+h] approached, but did not achieve, significant tumor weight reduction in Study 2/Fig 7E).