MMP9 and colorectal carcinoma: The prevalence of upregulated MMP9 in inflammatory indications such as UC suggests that a selective inhibitor of MMP9 could have substantial therapeutic impact: UC patients represent an unmet clinical need, since none of the current therapies result in widespread remission or in mucosal healing [44, 105] and because UC patients are at an increased risk for CRC [15, 31–33].